23669-79-6
Chemical Structure
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Synonym(s): 5'-O-DMT-dU
- CAS No.: 23669-79-6
- Formula:C30H30N2O7
- Molecular Weight:530.57
IUPAC Name: 1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: BYGKUWPLEGHFKX-ZRRKCSAHSA-N
SMILES: COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](O)C[C@@H](O3)N4C=CC(NC4=O)=O)C5=CC=CC=C5)C=C1
Biological Activity: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks[1][2].
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5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine | 98.20% | 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks. | ||||||||||||||||||||
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References
- [1]. Hidalgo-Zarco F, et, al. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major. Protein Sci. 2001 Jul;10(7):1426-33. [Content Brief]
- [2]. Hovinen J, et, al. Versatile strategy for oligonucleotide derivatization. Introduction of lanthanide(III) chelates to oligonucleotides. Org Lett. 2001 Aug 9;3(16):2473-6. [Content Brief]
