2368950-15-4
2368950-15-4
Chemical Structure
Ponsegromab
Synonym(s): PF-06946860
- CAS No.: 2368950-15-4
- Formula:N/A
- Molecular Weight:(145.5 kDa)
SMILES: [Ponsegromab]
Biological Activity: Ponsegromab is a Growth differentiation factor 15 (GDF15) inhibitor with human, cynomolgus monkey, and mouse target IC50 values of 0.123 nM, 0.053 nM, and 0.102 nM, respectively[1][2]. Ponsegromab acts as a chemosensitizer, increases intracellular reactive oxygen species, reduces glutathione levels[1][2]. Ponsegromab can be used for the research of oxaliplatin-resistant colorectal cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Ponsegromab | 99.60% | Ponsegromab is a Growth differentiation factor 15 (GDF15) inhibitor with human, cynomolgus monkey, and mouse target IC50 values of 0.123 nM, 0.053 nM, and 0.102 nM, respectively. Ponsegromab acts as a chemosensitizer, increases intracellular reactive oxygen species, reduces glutathione levels. Ponsegromab can be used for the research of oxaliplatin-resistant colorectal cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Huang Y, et al. GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models. MAbs. 2024;16(1):2416453. [Content Brief]
- [2]. Lin H, et al. GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer. Cell Oncol (Dordr). 2024;47(4):1149-1165. [Content Brief]
