2369981-71-3
Chemical Structure
CDK9-IN-7
- CAS No.: 2369981-71-3
- Formula:C29H37N7O2S
- Molecular Weight:547.71
IUPAC Name: 7-cyclopentyl-2-((4-(8-isothiocyanatooctanamido)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
InChIKey: LLMKBTGLZJIAMY-UHFFFAOYSA-N
SMILES: O=C(N(C)C)C1=CC2=CN=C(NC3=CC=C(NC(CCCCCCCN=C=S)=O)C=C3)N=C2N1C4CCCC4
Biological Activity: CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CDK9-IN-7 | 98.05% | CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC. | ||||||||||||||||||||
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