237068-57-4
Chemical Structure
Oglufanide disodium
Synonym(s): H-Glu-Trp-OH disodium; L-Glutamyl-L-tryptophan disodium
- CAS No.: 237068-57-4
- Formula:C16H17N3Na2O5
- Molecular Weight:377.30
IUPAC Name: sodium (S)-4-amino-5-(((S)-1-carboxylato-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoate
InChIKey: GDLPAGOVHZLZEK-JBUFHSOLSA-L
SMILES: O=C(O[Na])CC[C@H](N)C(N[C@H](C(O[Na])=O)CC1=CNC2=CC=CC=C12)=O
Biological Activity: Oglufanide (H-Glu-Trp-OH) disodium is a dipeptide immunomodulator isolated from calf thymus. Oglufanide disodium inhibits vascular endothelial growth factor (VEGF). Oglufanide disodium can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide disodium shows antitumor and anti-angiogenesis activities[1][2][3].
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Oglufanide disodium | Oglufanide (H-Glu-Trp-OH) disodium is a dipeptide immunomodulator isolated from calf thymus. Oglufanide disodium inhibits vascular endothelial growth factor (VEGF). Oglufanide disodium can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide disodium shows antitumor and anti-angiogenesis activities. | |||||||||||||||||||||
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References
- [1]. Bayes M, et al. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27(6):411-61. [Content Brief]
- [2]. Nagendra Kumar Kaushik, et al. Biomedical importance of indoles. Molecules. 2013 Jun 6;18(6):6620-62. [Content Brief]
- [3]. Noy A, et al. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team. J Clin Oncol. 2005 Feb 10;23(5):990-8. [Content Brief]
