2374699-35-9
Chemical Structure
JH-XIII-05-01
- CAS No.: 2374699-35-9
- Formula:C46H51N11O10
- Molecular Weight:917.96
IUPAC Name: N-(3-(1-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperidin-4-yl)-1-(pyridin-2-yl)-1H-pyrazol-5-yl)-6-(1H-pyrazol-5-yl)picolinamide
InChIKey: OYHCKWFUEKWODK-UHFFFAOYSA-N
SMILES: O=C(C1=NC(C2=CC=NN2)=CC=C1)NC3=CC(C4CCN(C(CCOCCOCCOCCOCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)CC4)=NN3C8=CC=CC=N8
Biological Activity: JH-XIII-05-01 is a cereblon-recruiting PROTAC degrader targeting IRAK1 and IRAK4, with DC50 values of 0.065 μM and 3.63 μM, respectively (TMD8 cells). JH-XIII-05-01 reduces cancer cell viability, induces apoptosis in primary MYD88-mutant WM cells and MYD88-mutant/wild-type lymphoma cells, and selectively degrades additional cereblon neosubstrates and kinases IKZF1, IKZF3, CSNK1A1, CSNK1D, CSNK1E, and PAK4. JH-XIII-05-01 can be used for research on Waldenström macroglobulinemia, diffuse large B-cell lymphoma, and B-cell lymphoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JH-XIII-05-01 | JH-XIII-05-01 is a cereblon-recruiting PROTAC degrader targeting IRAK1 and IRAK4, with DC50 values of 0.065 μM and 3.63 μM, respectively (TMD8 cells). JH-XIII-05-01 reduces cancer cell viability, induces apoptosis in primary MYD88-mutant WM cells and MYD88-mutant/wild-type lymphoma cells, and selectively degrades additional cereblon neosubstrates and kinases IKZF1, IKZF3, CSNK1A1, CSNK1D, CSNK1E, and PAK4. JH-XIII-05-01 can be used for research on Waldenström macroglobulinemia, diffuse large B-cell lymphoma, and B-cell lymphoma. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
