2375196-40-8
2375196-40-8
Chemical Structure
TNIK-IN-6
- CAS No.: 2375196-40-8
- Formula:C13H8BrFN4
- Molecular Weight:319.13
InChIKey: KARJFNUGCLEZKM-UHFFFAOYSA-N
SMILES: FC1=NC=CC(C2=NC3=C(N)N=CC(Br)=C3C=C2)=C1
Biological Activity: TNIK-IN-6 (Compound 9) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK) and , with IC50 of 0.93 μM, that plays important roles in neurological and psychiatric disorders[1][2].
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TNIK-IN-6 | 98.28% | TNIK-IN-6 (Compound 9) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK) and , with IC50 of 0.93 μM, that plays important roles in neurological and psychiatric disorders. | ||||||||||||||||||||
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References
- [1]. Koc-Kan Ho, et al. Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett. 2013 Jan 15;23(2):569-73. [Content Brief]
- [2]. Jon Read, et al. Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1962-1967. [Content Brief]
