2375242-78-5
Chemical Structure
sSPhos Pd G2
- CAS No.: 2375242-78-5
- Formula:C38H44ClNNaO5PPdS
- Molecular Weight:822.66
IUPAC Name: 2-ethoxy-4-methyl-5-nitropyridine
InChIKey: MWQYWXJKMDRSJN-UHFFFAOYSA-L
SMILES: Cl[Pd]1([P](C2CCCCC2)(C3CCCCC3)C4=CC=CC=C4C5=C(OC)C=CC(S(=O)(O[Na])=O)=C5OC)C6=CC=CC=C6C7=CC=CC=C7[NH2]1
Biological Activity: sSPhos Pd G2 is a water-soluble palladium catalyst. sSPhos Pd G2 mediates Suzuki-Miyaura cross-coupling reactions for protein biotinylation and on-DNA reactions, thereby enabling robust gel-based ABPP using iodocysteine-reactive probes rather than bromo- or chloro-substituted probes[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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sSPhos Pd G2 | 95.0% | sSPhos Pd G2 is a water-soluble palladium catalyst. sSPhos Pd G2 mediates Suzuki-Miyaura cross-coupling reactions for protein biotinylation and on-DNA reactions, thereby enabling robust gel-based ABPP using iodocysteine-reactive probes rather than bromo- or chloro-substituted probes. | ||||||||||||||||||||
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References
- [1]. Chen A, et al. Palladium-catalyzed Suzuki-Miyaura cross-couplings of stable glycal boronates for robust synthesis of C-1 glycals. Nature communications. 2024 Jun 19;15(1):5228.
- [2]. Cao J, et al. Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Analytical chemistry. 2021 Feb 02;93(4):2610-2618.
- [3]. Liu W, et al. Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide. Bioorganic & medicinal chemistry. 2021 May 15;38:116118.
- [4]. Li JY, et al. Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis. Bioconjugate chemistry. 2019 Aug 21;30(8):2209-2215.
- [5]. Li JY, et al. Development of DNA-Compatible Suzuki-Miyaura Reaction in Aqueous Media. Bioconjugate chemistry. 2018 Nov 21;29(11):3841-3846.
- [6]. Cao J, et al. Suzuki–Miyaura cross-coupling for chemoproteomic applications.