2376132-22-6
Chemical Structure
KARI 201
- CAS No.: 2376132-22-6
- Formula:C14H28N4O2
- Molecular Weight:284.40
InChIKey: ZPXWKEHHIIOEAC-UHFFFAOYSA-N
SMILES: NC(CO)(CO)C(N=N1)=CN1CCCCCCCCC
Biological Activity: KARI 201 is an orally active, blood-brain barrier-penetrant bifunctional small molecule. KARI 201 is a selective inhibitor of ASM and an agonist of GHSR-1a. KARI 201 competitively binds ASM, inhibits ASM activity to reduce intracellular ceramide levels, restores lysosomal biogenesis, and repairs impaired autophagic flux in neurons. KARI 201 activates GHSR-1a and induces calcium influx. KARI 201 ameliorates Alzheimer's disease-related pathology, age-related sarcopenia phenotypes, and postoperative ileus-related symptoms. KARI 201 can be used in Alzheimer's disease-related research[1][2].
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KARI 201 | KARI 201 is an orally active, blood-brain barrier-penetrant bifunctional small molecule. KARI 201 is a selective inhibitor of ASM and an agonist of GHSR-1a. KARI 201 competitively binds ASM, inhibits ASM activity to reduce intracellular ceramide levels, restores lysosomal biogenesis, and repairs impaired autophagic flux in neurons. KARI 201 activates GHSR-1a and induces calcium influx. KARI 201 ameliorates Alzheimer's disease-related pathology, age-related sarcopenia phenotypes, and postoperative ileus-related symptoms. KARI 201 can be used in Alzheimer's disease-related research. | |||||||||||||||||||||
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References
- [1]. Park MH, et al. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America. 2022 Jan 18;119(3):e2115082119. [Content Brief]
- [2]. Yoon HJ, et al. KARIs, Ghrelin Receptor Agonists With Excellent Brain Permeability, Increase Food Intake and Attenuate the Muscle Loss in Mice. Journal of cachexia, sarcopenia and muscle. 2026 Apr;17(2):e70277.
