2376132-24-8
Chemical Structure
KARI 201 hydrochloride
- CAS No.: 2376132-24-8
- Formula:C14H29ClN4O2
- Molecular Weight:320.86
InChIKey: HOTAZHVFANOVID-UHFFFAOYSA-N
SMILES: NC(CO)(CO)C(N=N1)=CN1CCCCCCCCC.Cl
Biological Activity: KARI 201 hydrochloride is an orally active, blood-brain barrier-penetrant bifunctional small molecule. KARI 201 hydrochloride is a selective inhibitor of ASM and an agonist of GHSR-1a. KARI 201 hydrochloride competitively binds ASM, inhibits ASM activity to reduce intracellular ceramide levels, restores lysosomal biogenesis, and repairs impaired autophagic flux in neurons. KARI 201 hydrochloride activates GHSR-1a and induces calcium influx. KARI 201 hydrochloride ameliorates Alzheimer's disease-related pathology, age-related sarcopenia phenotypes, and postoperative ileus-related symptoms. KARI 201 hydrochloride can be used in Alzheimer's disease-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KARI 201 hydrochloride | 99.94% | KARI 201 hydrochloride is an orally active, blood-brain barrier-penetrant bifunctional small molecule. KARI 201 hydrochloride is a selective inhibitor of ASM and an agonist of GHSR-1a. KARI 201 hydrochloride competitively binds ASM, inhibits ASM activity to reduce intracellular ceramide levels, restores lysosomal biogenesis, and repairs impaired autophagic flux in neurons. KARI 201 hydrochloride activates GHSR-1a and induces calcium influx. KARI 201 hydrochloride ameliorates Alzheimer's disease-related pathology, age-related sarcopenia phenotypes, and postoperative ileus-related symptoms. KARI 201 hydrochloride can be used in Alzheimer's disease-related research. | ||||||||||||||||||||
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References
- [1]. Park MH, et al. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America. 2022 Jan 18;119(3):e2115082119. [Content Brief]
- [2]. Yoon HJ, et al. KARIs, Ghrelin Receptor Agonists With Excellent Brain Permeability, Increase Food Intake and Attenuate the Muscle Loss in Mice. Journal of cachexia, sarcopenia and muscle. 2026 Apr;17(2):e70277.
