2376765-57-8
Chemical Structure
DSP-0390
- CAS No.: 2376765-57-8
- Formula:C23H30ClN3O2
- Molecular Weight:415.96
IUPAC Name: (4a'R,10b'R)-1-(2-(1H-imidazol-1-yl)ethyl)-8'-chloro-5',5'-dimethyl-4a',10b'-dihydro-2'H,4'H,5'H-spiro[piperidine-4,3'-pyrano[3,2-c]chromene]
InChIKey: QKAZUVQTHFXMLS-CTNGQTDRSA-N
SMILES: CC1([C@]2([H])CC3(CCN(CC3)CCN4C=CN=C4)CO[C@@]2([H])C5=CC=C(Cl)C=C5O1)C
Biological Activity: DSP-0390 is an orally active inhibitor of emopamil binding protein (EBP). DSP-0390 induces cell death by blocking cholesterol biosynthesis in tumor cells. DSP-0390 exhibits antitumor activity in an orthotopic xenograft model of human glioblastoma. DSP-0390 can be used for the research of recurrent high-grade gliomas[1].
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DSP-0390 | DSP-0390 is an orally active inhibitor of emopamil binding protein (EBP). DSP-0390 induces cell death by blocking cholesterol biosynthesis in tumor cells. DSP-0390 exhibits antitumor activity in an orthotopic xenograft model of human glioblastoma. DSP-0390 can be used for the research of recurrent high-grade gliomas. | |||||||||||||||||||||
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