2377379-39-8
Chemical Structure
MRGPRX1 agonist 1
- CAS No.: 2377379-39-8
- Formula:C23H21N3O4S
- Molecular Weight:435.50
IUPAC Name: N-(2-((1-aminoisoquinolin-6-yl)oxy)-4-methylphenyl)-2-methoxybenzenesulfonamide
InChIKey: BWEJNHRMGZUMNU-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC=C1OC)(NC2=CC=C(C)C=C2OC3=CC4=C(C(N)=NC=C4)C=C3)=O
Biological Activity: MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist (EC50=50 nM) with greater than 50-fold selectivity for δ, μ, and κ opioid receptors. MRGPRX1 agonist 1 is inactive against MRGPRC11. MRGPRC11 inhibits high voltage-activated (HVA) Ca2+ currents, reduces neurotransmitter release, and mitigates nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is useful for the study of chronic pain, especially neuropathic pain[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MRGPRX1 agonist 1 | 99.95% | MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist (EC50=50 nM) with greater than 50-fold selectivity for δ, μ, and κ opioid receptors. MRGPRX1 agonist 1 is inactive against MRGPRC11. MRGPRC11 inhibits high voltage-activated (HVA) Ca2+ currents, reduces neurotransmitter release, and mitigates nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is useful for the study of chronic pain, especially neuropathic pain. | ||||||||||||||||||||
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