2377778-85-1
Chemical Structure
MV14
- CAS No.: 2377778-85-1
- Formula:C15H19N3O7S
- Molecular Weight:385.39
InChIKey: ILGUKIUEABAAAD-UHFFFAOYSA-N
SMILES: [O-][N+]1=C(S(=O)(C2=CC=CC=C2)=O)C(OCCNC(OC(C)(C)C)=O)=NO1
Biological Activity: MV14 is a small-molecule NO donor that exhibits selective antiproliferative activity against bladder cancer cells. MV14 releases NO, causing DNA double-strand damage, inhibiting the NF‑κB pathway, and downregulating the apoptosis-inhibitory protein Survivin. MV14 interferes with the cell cycle and promotes tumor cell apoptosis. MV14 attenuates tumor-associated histopathological changes, urothelial destruction, and stromal invasion in the BBN (HY-W755252)-induced mouse bladder cancer model, and reduces PCNA levels in bladder tumor tissue while increasing active caspase-3. MV14 can be used for research on bladder cancer[1].
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MV14 | MV14 is a small-molecule NO donor that exhibits selective antiproliferative activity against bladder cancer cells. MV14 releases NO, causing DNA double-strand damage, inhibiting the NF‑κB pathway, and downregulating the apoptosis-inhibitory protein Survivin. MV14 interferes with the cell cycle and promotes tumor cell apoptosis. MV14 attenuates tumor-associated histopathological changes, urothelial destruction, and stromal invasion in the BBN (HY-W755252)-induced mouse bladder cancer model, and reduces PCNA levels in bladder tumor tissue while increasing active caspase-3. MV14 can be used for research on bladder cancer. | |||||||||||||||||||||
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