2378039-23-5
2378039-23-5
Chemical Structure
PY109
- CAS No.: 2378039-23-5
- Formula:C15H9F3N2O
- Molecular Weight:290.24
IUPAC Name: 5-phenyl-3-(pyridin-4-yl)pyrazin-2-amine
InChIKey: LANJLFOCGPBZLQ-UHFFFAOYSA-N
SMILES: O=C(C1=CNC2=C1C=CC=C2)C3=NC(C(F)(F)F)=CC=C3
Biological Activity: PY109 is an orally active and highly selective aryl hydrocarbon receptor (AHR) agonist. PY109's EC50 values in human-derived HepG2 and mouse Hepa-1c1c7 cells are 1.2 nM and 1.4 nM respectively. PY109 significantly upregulates the expression of CYP1A1 and IL-22, and inhibits the expression of IL-17A. PY109 significantly improves colitis in mice. PY109 can be used for research on colitis[1].
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PY109 | 99.15% | PY109 is an orally active and highly selective aryl hydrocarbon receptor (AHR) agonist. PY109's EC50 values in human-derived HepG2 and mouse Hepa-1c1c7 cells are 1.2 nM and 1.4 nM respectively. PY109 significantly upregulates the expression of CYP1A1 and IL-22, and inhibits the expression of IL-17A. PY109 significantly improves colitis in mice. PY109 can be used for research on colitis. | ||||||||||||||||||||
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