2378380-49-3
2378380-49-3
Chemical Structure
Pelecopan
Synonym(s): BCX9930
- CAS No.: 2378380-49-3
- Formula:C23H19FN2O4
- Molecular Weight:406.41
IUPAC Name: 2-(2-((7-(2-(aminomethyl)-3-fluoropyridin-4-yl)benzofuran-5-yl)methoxy)phenyl)acetic acid
InChIKey: AUARNXJEAZFQCQ-UHFFFAOYSA-N
SMILES: O=C(CC1=C(OCC2=CC3=C(C(C4=C(F)C(CN)=NC=C4)=C2)OC=C3)C=CC=C1)O
Biological Activity: Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pelecopan | 98.07% | Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases. | ||||||||||||||||||||
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References
- [1]. International Nonproprietary Names for Pharmaceutical Substances (INN)
- [2]. AustinKulasekararajMD MRCP, FRCPath, et al. BCX9930, a Potent, Selective, Oral Factor D Inhibitor, Demonstrates Proof-of-Concept As Monotherapy in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH). Blood (2020) Volume 136, Supplement 1, 5 November 2
- [3]. XilinChenMDPhD, et al. Preclinical Characterization of BCX9930, a Potent Oral Complement Factor D Inhibitor, Targeting Alternative Pathway-Mediated Diseases Including Paroxysmal Nocturnal Hemoglobinuria (PNH). Blood (2020) Volume 136, Supplement 1, 5 Nove
