2379672-57-6
Chemical Structure
PROTAC ALK degrader-5
- CAS No.: 2379672-57-6
- Formula:C40H37N7O6
- Molecular Weight:711.77
InChIKey: UMEMOEKJTJMMJN-UHFFFAOYSA-N
SMILES: O=C(N1)C(N2C(C3=CC=CC(NCC(N4CCN(C5=CC(C6(C)C)=C(C(C7=C6NC8=C7C=CC(C#N)=C8)=O)C=C5CC)CC4)=O)=C3C2=O)=O)CCC1=O
Biological Activity: PROTAC ALK degrader-5 (Compound 17) is an efficient ALK PROTAC degrader, with its inhibitory effects on EML4-ALK and NPM-ALK being 27.4 nM and 116.5 nM respectively. PROTAC ALK degrader-5 exhibits potent anti-proliferative activity against H3122 and Karpas 299. PROTAC ALK degrader-5 effectively inhibits the phosphorylation of ALK and STAT3. PROTAC ALK degrader-5 can be used for the study of ALK-driven malignant tumors, such as human non-small cell lung cancer and anaplastic large cell lymphoma[1].
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PROTAC ALK degrader-5 | PROTAC ALK degrader-5 (Compound 17) is an efficient ALK PROTAC degrader, with its inhibitory effects on EML4-ALK and NPM-ALK being 27.4 nM and 116.5 nM respectively. PROTAC ALK degrader-5 exhibits potent anti-proliferative activity against H3122 and Karpas 299. PROTAC ALK degrader-5 effectively inhibits the phosphorylation of ALK and STAT3. PROTAC ALK degrader-5 can be used for the study of ALK-driven malignant tumors, such as human non-small cell lung cancer and anaplastic large cell lymphoma. | |||||||||||||||||||||
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