2380016-80-6
Chemical Structure
3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA
- CAS No.: 2380016-80-6
- Formula:C51H93N11O20
- Molecular Weight:1180.35
InChIKey: AIQQFWHJUOAGIB-UHFFFAOYSA-N
SMILES: OC(CN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CCN1CC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC(NCCCC2=NN=C(C)N=N2)=O)=O)=O)=O
Biological Activity: 3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA is a bioorthogonal activator. 3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA reacts with the TCO linker of the ADC via inverse electron-demand Diels-Alder coupling, triggering pyridazine elimination and allylic carbamate cleavage to release MMAE (HY-15162). The presence of the DOTA chelate in 3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA enables 111In labeling and single-photon emission computed tomography/computed tomography (SPECT/CT), allowing direct imaging of the reaction between 3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA and the tumor-bound tc-ADC[1].
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3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA | 3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA is a bioorthogonal activator. 3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA reacts with the TCO linker of the ADC via inverse electron-demand Diels-Alder coupling, triggering pyridazine elimination and allylic carbamate cleavage to release MMAE (HY-15162). The presence of the DOTA chelate in 3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA enables 111In labeling and single-photon emission computed tomography/computed tomography (SPECT/CT), allowing direct imaging of the reaction between 3-Methyl-6-trimethylene-tetrazine-PEG11-DOTA and the tumor-bound tc-ADC. | |||||||||||||||||||||
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