2380321-50-4
2380321-50-4
Chemical Structure
CDK4/6-IN-5
- CAS No.: 2380321-50-4
- Formula:C22H28ClFN6O4S
- Molecular Weight:527.01
IUPAC Name: (3R,4R)-4-((5-chloro-4-(4-fluoro-2-((R)-1-hydroxyethyl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)-1-(methylsulfonyl)piperidin-3-ol
InChIKey: KSCSDVHAZVSGAW-XHBKTUGNSA-N
SMILES: CC(N1C2=CC(C3=NC(N[C@H]4[C@@H](CN(CC4)S(C)(=O)=O)O)=NC=C3Cl)=CC(F)=C2N=C1[C@H](O)C)C
Biological Activity: CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. (from patent WO2019207463A1 example A93).
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CDK4/6-IN-5 | CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. (from patent WO2019207463A1 example A93). | |||||||||||||||||||||
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