23806-24-8
Chemical Structure
3-Methylthiophene-2-carboxylic acid
- CAS No.: 23806-24-8
- Formula:C6H6O2S
- Molecular Weight:142.18
IUPAC Name: 3-methylthiophene-2-carboxylic acid
InChIKey: IFLKEBSJTZGCJG-UHFFFAOYSA-N
SMILES: CC(C=CS1)=C1C(O)=O
Biological Activity: 3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a Kd of 19.6 µM and an IC50 of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research[1].
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3-Methylthiophene-2-carboxylic acid | 3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E (PqsE) inhibitor with a Kd of 19.6 µM and an IC50 of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research. | |||||||||||||||||||||
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