238742-88-6
238742-88-6
Chemical Structure
Fmoc-D-Phe(4-CF3)-OH
- CAS No.: 238742-88-6
- Formula:C25H20F3NO4
- Molecular Weight:455.43
IUPAC Name: (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid
InChIKey: YMEGJWTUWMVZPD-JOCHJYFZSA-N
SMILES: O=C(O)[C@@H](CC1=CC=C(C(F)(F)F)C=C1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O
Biological Activity: Fmoc-D-Phe (4-CF3)-OH is a D-phenylalanine derivative bearing an Fmoc protecting group. Fmoc-D-Phe (4-CF3)-OH serves primarily as a key structural building block in solid-phase peptide synthesis (SPPS). Fmoc-D-Phe (4-CF3)-OH can be used in the study of peptide inhibitors of protein-protein interactions[1][2][3].
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Fmoc-D-Phe(4-CF3)-OH | 99.09% | Fmoc-D-Phe (4-CF3)-OH is a D-phenylalanine derivative bearing an Fmoc protecting group. Fmoc-D-Phe (4-CF3)-OH serves primarily as a key structural building block in solid-phase peptide synthesis (SPPS). Fmoc-D-Phe (4-CF3)-OH can be used in the study of peptide inhibitors of protein-protein interactions. | ||||||||||||||||||||
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References
- [1]. Xu J, et al. Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection. Journal of medicinal chemistry. 2020 Mar 26;63(6):3142-3160. [Content Brief]
- [2]. Mowlazadeh Haghighi S, et al. Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation. Eur J Med Chem. 2018;151:815-823.
- [3]. Hubert Chen, et al. Peptidomimetic macrocycles and uses thereof. WO2016049359A1. WIPO. 2016-03-31.
