239101-33-8
239101-33-8
Chemical Structure
Deferitrin
Synonym(s): GT-56-252
- CAS No.: 239101-33-8
- Formula:C11H11NO4S
- Molecular Weight:253.27
IUPAC Name: (S)-2-(2,4-dihydroxyphenyl)-4-methyl-4,5-dihydrothiazole-4-carboxylic acid
InChIKey: OEUUFNIKLCFNLN-LLVKDONJSA-N
SMILES: O=C([C@]1(C)N=C(C2=CC=C(O)C=C2O)SC1)O
Biological Activity: Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2].
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Deferitrin | 98.25% | Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major. | ||||||||||||||||||||
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References
- [1]. Raymond J Bergeron, et al. Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues. J Med Chem. 2008 Jul 10;51(13):3913-23. [Content Brief]
- [2]. Joanne M Donovan, et al. Preclinical and Clinical Development of Deferitrin, a Novel, Orally Available Iron Chelator. Ann N Y Acad Sci. 2005;1054:492-4. [Content Brief]
