2396664-85-8
2396664-85-8
Chemical Structure
FGFR4-IN-11
- CAS No.: 2396664-85-8
- Formula:C29H29N5O5
- Molecular Weight:527.57
IUPAC Name: N-(2-((3-(3,5-dimethoxybenzoyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-5-morpholinophenyl)acrylamide
InChIKey: YMFNEYWPMKYGQY-UHFFFAOYSA-N
SMILES: COC1=CC(C(C2=CNC3=NC(NC4=C(C=C(C=C4)N5CCOCC5)NC(C=C)=O)=CC=C32)=O)=CC(OC)=C1
Biological Activity: FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].
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FGFR4-IN-11 | FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity. | |||||||||||||||||||||
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