23982-76-5
23982-76-5
Chemical Structure
10-Cl-BBQ
- CAS No.: 23982-76-5
- Formula:C18H9ClN2O
- Molecular Weight:304.73
IUPAC Name: 10-chloro-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one
InChIKey: ZJESJVGSDQOZAT-UHFFFAOYSA-N
SMILES: O=C(N1C2=NC3=CC=C(C=C31)Cl)C4=CC=CC5=CC=CC2=C45
Biological Activity: 10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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10-Cl-BBQ | 99.46% | 10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations. | ||||||||||||||||||||
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References
- [1]. Sumit Punj, et al. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One. 2014 Feb 19;9(2):e88726. [Content Brief]
- [2]. Allison K Ehrlich, et al. Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice. J Immunol. 2016 Jan 1;196(1):264-73. [Content Brief]
