2403760-70-1
Chemical Structure
Dosimertinib
Synonym(s): Osimertinib-d5; AZD-9291-d5; Mereletinib-d5
- CAS No.: 2403760-70-1
- Formula:C28H28D5N7O2
- Molecular Weight:504.64
IUPAC Name: N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(methyl-d3)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide-3,3-d2
InChIKey: DUYJMQONPNNFPI-ZFTIYMCPSA-N
SMILES: [2H]/C([2H])=C\C(NC1=CC(NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C([2H])([2H])[2H])=N2)=C(C=C1N(CCN(C)C)C)OC)=O
Biological Activity: Dosimertinib is a potent and orally active EGFR inhibitor. Dosimertinib decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib shows antiproliferative and anti-tumor activity. Dosimertinib has the potential for the research of non-small-cell lung cancer (NSCLC)[1].
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Dosimertinib | Dosimertinib is a potent and orally active EGFR inhibitor. Dosimertinib decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib shows antiproliferative and anti-tumor activity. Dosimertinib has the potential for the research of non-small-cell lung cancer (NSCLC). | |||||||||||||||||||||
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