2407072-65-3
2407072-65-3
Chemical Structure
O-GlcNAcase-IN-6
- CAS No.: 2407072-65-3
- Formula:C20H25N5O
- Molecular Weight:351.45
InChIKey: BNCTZKXIAJVAOK-UHFFFAOYSA-N
SMILES: CC1=C(C(C(C)C)=NC=C1)NC2=C3C=CN(C3=CC=N2)CC(N(C)C)=O
Biological Activity: O-GlcNAcase-IN-6 is an orally active, blood-brain barrier-permeable O-GlcNAcase (OGA) inhibitor with an IC50 of 5.4 nM. O-GlcNAcase-IN-6 inhibits OGA activity, thereby increasing the level of O-GlcNAc glycosylation in brain tissues. O-GlcNAcase-IN-6 can be used for the research of Alzheimer's disease[1].
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O-GlcNAcase-IN-6 | O-GlcNAcase-IN-6 is an orally active, blood-brain barrier-permeable O-GlcNAcase (OGA) inhibitor with an IC50 of 5.4 nM. O-GlcNAcase-IN-6 inhibits OGA activity, thereby increasing the level of O-GlcNAc glycosylation in brain tissues. O-GlcNAcase-IN-6 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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