2407516-83-8
Chemical Structure
cGAMP disodium
Synonym(s): Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium
- CAS No.: 2407516-83-8
- Formula:C20H22N10Na2O13P2
- Molecular Weight:718.37
IUPAC Name: sodium (2R,3R,3aS,7aR,9R,10R,10aS,14aR)-2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-9-(6-amino-9H-purin-9-yl)-3,10-dihydroxyoctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine-5,12-bis(olate) 5,12-dioxide
InChIKey: MFPHQIYDBUVTRL-DQNSRKNCSA-L
SMILES: [H][C@@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@]1([C@H]([C@H](N6C=NC7=C6N=C(N)NC7=O)O2)O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O
Biological Activity: cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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cGAMP disodium | 98.47% | cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators. | ||||||||||||||||||||
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References
- [1]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. [Content Brief]
- [2]. Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. [Content Brief]
- [3]. Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4. [Content Brief]
