2407981-35-3
2407981-35-3
Chemical Structure
FM26
- CAS No.: 2407981-35-3
- Formula:C22H15ClF3N3O3
- Molecular Weight:461.82
IUPAC Name: 4-(((3-(2-chloro-6-(trifluoromethyl)phenyl)-5-(1H-pyrrol-3-yl)isoxazol-4-yl)methyl)amino)benzoic acid
InChIKey: KGEONJPJJNFHOI-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(NCC2=C(C3=CNC=C3)ON=C2C4=C(C(F)(F)F)C=CC=C4Cl)C=C1
Biological Activity: FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
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FM26 | FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. | |||||||||||||||||||||
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