2408065-32-5
Chemical Structure
PLN-1474
- CAS No.: 2408065-32-5
- Formula:C24H37N3O4
- Molecular Weight:431.57
IUPAC Name: (S)-2-(4-methyltetrahydro-2H-pyran-4-carboxamido)-9-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid
InChIKey: GELVLHVQVRSFAY-FQEVSTJZSA-N
SMILES: O=C(O)[C@H](CCCCCCCC1=CC=C2C(N1)=NCCC2)NC(C3(C)CCOCC3)=O
Biological Activity: PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder.
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PLN-1474 | 99.35% | PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder. | ||||||||||||||||||||
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