240814-54-4
240814-54-4
Chemical Structure
BMS-279700
- CAS No.: 240814-54-4
- Formula:C21H22ClN7
- Molecular Weight:407.90
IUPAC Name: (S)-N-(2-chloro-6-methylphenyl)-2-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine
InChIKey: PUNYTBZWCMNSRO-AWEZNQCLSA-N
SMILES: C[C@H](NCC1)CN1C2=CC=C3C(N4C(C(NC5=C(C=CC=C5Cl)C)=N3)=CN=C4)=N2
Biological Activity: BMS-279700 is an orally active Src-family kinase p56Lck inhibitor. BMS-279700 can block the production of proinflammatory cytokines (IL-2 and TNFα). BMS-279700 can inhibit T cell proliferation. BMS-279700 can be used for the researches of inflammation and immunology[1].
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BMS-279700 | BMS-279700 is an orally active Src-family kinase p56Lck inhibitor. BMS-279700 can block the production of proinflammatory cytokines (IL-2 and TNFα). BMS-279700 can inhibit T cell proliferation. BMS-279700 can be used for the researches of inflammation and immunology. | |||||||||||||||||||||
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References
- [1]. Chen P, et al. Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity. J Med Chem. 2004 Aug 26;47(18):4517-29. [Content Brief]
