2408297-80-1
Chemical Structure
EP3 antagonist 4
- CAS No.: 2408297-80-1
- Formula:C22H20Cl3FN4O3S2
- Molecular Weight:577.91
IUPAC Name: (Z)-5-chloro-N-((2-(1-(2,4-dichlorobenzyl)-1,4,5,6-tetrahydro-7H-indazol-7-ylidene)-2-fluoroethyl)carbamoyl)-4-methylthiophene-2-sulfonamide
InChIKey: FYUOIRIANAUUOH-VLGSPTGOSA-N
SMILES: O=S(NC(NC/C(F)=C1CCCC(C=N2)=C\1N2CC3=C(C=C(C=C3)Cl)Cl)=O)(C4=CC(C)=C(S4)Cl)=O
Biological Activity: EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes[1].
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EP3 antagonist 4 | EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes. | |||||||||||||||||||||
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