2408626-64-0
2408626-64-0
Chemical Structure
ThrRS-IN-1
- CAS No.: 2408626-64-0
- Formula:C16H18Cl2N4O3
- Molecular Weight:385.25
IUPAC Name: (2S,3R)-2-amino-N-((E)-4-(6,7-dichloro-4-oxoquinazolin-3(4H)-yl)but-2-en-1-yl)-3-hydroxybutanamide
InChIKey: YXMAQAPNMNRQQB-XKKUMHBKSA-N
SMILES: O=C1N(C/C=C/CNC([C@@H](N)[C@H](O)C)=O)C=NC2=CC(Cl)=C(Cl)C=C21
Biological Activity: ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].
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ThrRS-IN-1 | ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities. | |||||||||||||||||||||
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