2409538-60-7
2409538-60-7
Chemical Structure
Igermetostat
Synonym(s): XNW5004
- CAS No.: 2409538-60-7
- Formula:C32H46N4O4
- Molecular Weight:550.73
InChIKey: YGNGDDWFJFOIGX-DIVCQZSQSA-N
SMILES: O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(O[C@H]3C[C@H](N4CCCCC4)C3)=CC(N(CC)C5CCOCC5)=C2C
Biological Activity: Igermetostat (XNW5004) is an orally active EZH2 inhibitor for research related to metastatic castration-resistant prostate cancer[1][2].
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Igermetostat | Igermetostat (XNW5004) is an orally active EZH2 inhibitor for research related to metastatic castration-resistant prostate cancer. | |||||||||||||||||||||
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References
- [1]. Chang Y, et al. A phase 1b/2 study to evaluate the safety and efficacy of igermetostat (XNW5004) in combination with enzalutamide in patients with metastatic castration‑resistant prostate cancer. Journal of Clinical Oncology. 2026;44(7_suppl):169.
- [2]. Louati K, et al. The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets. Journal of proteome research. 2025 Sep 05;24(9):4503-4525.
