2409543-84-4
2409543-84-4
Chemical Structure
Itacnosertib hydrochloride
Synonym(s): TP-0184 hydrochloride
- CAS No.: 2409543-84-4
- Formula:C26H29ClN8O
- Molecular Weight:505.01
InChIKey: ABZRWCMUFGOVSR-UHFFFAOYSA-N
SMILES: CN1CCN(C2=CC=C(NC3=NC=CC(NC4=CC=CN=C4C5=NC=CC=C5)=N3)C=C2OC)CC1.[H]Cl
Biological Activity: Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity[1][2].
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Itacnosertib hydrochloride | 99.43% | Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity. | ||||||||||||||||||||
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Itacnosertib hydrochloride (Standard) | ≥98% | Itacnosertib hydrochloride (Standard) is the analytical standard of Itacnosertib (hydrochloride) (HY-109179A). This product is intended for research and analytical applications. Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity. | ||||||||||||||||||||
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References
- [1]. Mollard A, et al. Preparation of [(piperazinylphenyl)amino]pyrimidine derivatives as JAK2 and ALK2 inhibitors. WO2014151871A2. 2014-09-25.
- [2]. Tyagi A, et al., TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax. Leukemia. 2024 Jan;38(1):82-95. [Content Brief]
