2409725-49-9
2409725-49-9
Chemical Structure
PI3Kδ-IN-10
- CAS No.: 2409725-49-9
- Formula:C19H16ClN9
- Molecular Weight:405.84
IUPAC Name: (S)-2,4-diamino-6-((1-(6-chloro-1-(pyridin-3-yl)-1H-indazol-3-yl)ethyl)amino)pyrimidine-5-carbonitrile
InChIKey: VGSSLTPCGYPSOR-JTQLQIEISA-N
SMILES: N#CC1=C(N[C@H](C2=NN(C3=CC=CN=C3)C4=C2C=CC(Cl)=C4)C)N=C(N)N=C1N
Biological Activity: PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor with IC50 of 2 nM. PI3Kδ-IN-10 robustly suppresses the downstream AKT pathway to induce subsequent apoptosis in hepatocellular carcinoma models[1].
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PI3Kδ-IN-10 | PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor with IC50 of 2 nM. PI3Kδ-IN-10 robustly suppresses the downstream AKT pathway to induce subsequent apoptosis in hepatocellular carcinoma models. | |||||||||||||||||||||
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