2409826-23-7
2409826-23-7
Chemical Structure
NIC-12
- CAS No.: 2409826-23-7
- Formula:C22H28ClN5O2S
- Molecular Weight:462.01
InChIKey: DPKFNVWTDOYMQY-OAHLLOKOSA-N
SMILES: CC(C1=NN(C(C2=CC3=C(N21)C=C(S3)Cl)=O)CC(N[C@@H]4CCCN(C4)CC5CC5)=O)C
Biological Activity: NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages[1].
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NIC-12 | NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages. | |||||||||||||||||||||
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