2409960-12-7
2409960-12-7
Chemical Structure
YT 6-2 analog-1
- CAS No.: 2409960-12-7
- Formula:C23H20F2O4
- Molecular Weight:398.40
InChIKey: GNDKFAQABPKYKM-NRFANRHFSA-N
SMILES: FC1=CC=C(C=C1)COC2=CC=C(OC[C@@H]3OC3)C=C2OCC4=CC=C(F)C=C4
Biological Activity: YT 6-2 analog-1 (compound 2-3) is the p62/SQSTM1 targeting, autophagy-targeting ligand (ATL) of AUTOTAC ATC-324 (HY-169385), which is an bivalent AR (Androgen Receptor) degrader. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa[1].
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YT 6-2 analog-1 | 99.13% | YT 6-2 analog-1 (compound 2-3) is the p62/SQSTM1 targeting, autophagy-targeting ligand (ATL) of AUTOTAC ATC-324 (HY-169385), which is an bivalent AR (Androgen Receptor) degrader. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa. | ||||||||||||||||||||
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