2410056-27-6
2410056-27-6
Chemical Structure
FAK inhibitor 6
- CAS No.: 2410056-27-6
- Formula:C25H24FN5O2S
- Molecular Weight:477.55
IUPAC Name: 2-fluoro-4-((7-(2-methoxyphenyl)thieno[3,2-d]pyrimidin-2-yl)amino)-N-(piperidin-4-yl)benzamide
InChIKey: NHLMMNCVSWYEIL-UHFFFAOYSA-N
SMILES: COC1=CC=CC=C1C2=CSC3=CN=C(N=C32)NC4=CC(F)=C(C=C4)C(NC5CCNCC5)=O
Biological Activity: Compound 26F not only optimized the effective inhibitory enzyme (ic50= 28.2 nm), but also showed relatively less cytotoxicity (ic50= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase.
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FAK inhibitor 6 | Compound 26F not only optimized the effective inhibitory enzyme (ic50= 28.2 nm), but also showed relatively less cytotoxicity (ic50= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase. | |||||||||||||||||||||
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