2410081-58-0
2410081-58-0
Chemical Structure
Fumagilin-105
- CAS No.: 2410081-58-0
- Formula:C46H60N2O9
- Molecular Weight:784.98
InChIKey: SVBWUBDTABZRQC-IKTQTWKJSA-N
SMILES: C[C@]1([C@H](O1)C/C=C(C)\C)[C@]2([H])[C@]3(CC[C@H]([C@H]2OC)OC(/C=C/C=C/C=C/C=C/C(NCCOCCOCCNCC4=CC(OCC5=CC=CC=C5)=CC=C4)=O)=O)CO3
Biological Activity: Fumagilin-105 is an autophagy-targeting chimera (AUTOTAC) that degrades MetAP2 via p62-mediated macroautophagy in a ubiquitination-independent manner. Fumagilin-105 can inhibit the migration of tumor cells and induce programmed cell death. Fumagilin-105 has anti-tumor activity. (p62-ZZ ligand (HY-W489121); target-binding ligand (HY-B0751); linker (HY-W245803))[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fumagilin-105 | 97.34% | Fumagilin-105 is an autophagy-targeting chimera (AUTOTAC) that degrades MetAP2 via p62-mediated macroautophagy in a ubiquitination-independent manner. Fumagilin-105 can inhibit the migration of tumor cells and induce programmed cell death. Fumagilin-105 has anti-tumor activity. (p62-ZZ ligand (HY-W489121); target-binding ligand (HY-B0751); linker (HY-W245803)). | ||||||||||||||||||||
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