2410423-31-1
2410423-31-1
Chemical Structure
IKKβ-IN-1
- CAS No.: 2410423-31-1
- Formula:C31H30N4O4S
- Molecular Weight:554.66
IUPAC Name: (Z)-4-(4-((3-(4-(3-(4-methylpiperazin-1-yl)propoxy)phenyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)benzonitrile
InChIKey: HACZQYUWEAIJNO-ANYBSYGZSA-N
SMILES: N#CC1=CC=C(OC2=CC=C(/C=C(SC(N3C4=CC=C(OCCCN5CCN(C)CC5)C=C4)=O)/C3=O)C=C2)C=C1
Biological Activity: IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC50 of 0.20 μM. IKKβ-IN-1 can reduce PGE2 and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality[1].
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IKKβ-IN-1 | IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC50 of 0.20 μM. IKKβ-IN-1 can reduce PGE2 and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality. | |||||||||||||||||||||
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