2410782-67-9
2410782-67-9
Chemical Structure
SMU-H1
- CAS No.: 2410782-67-9
- Formula:C18H16F3N3O3S
- Molecular Weight:411.40
InChIKey: CGOUTOGEUJUGTP-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(NC)C(N2C=C(C3=CC=C(C(F)(F)F)C=C3O)N=C2)=C1)(C)=O
Biological Activity: SMU-H1 is a TLR2 agonist with a KD of 12.1 nM for mouse TLR2 and an EC50 of 5.14 nM in HEK-Blue hTLR2 cells. SMU-H1 binds TLR2 and activates MyD88-dependent signaling. SMU-H1 activates the NF-κB and MAPK signaling pathways. SMU-H1 induces proinflammatory cytokine production. SMU-H1 promotes M1 macrophage polarization and dendritic cell activation. SMU-H1 can be used for research on Lewis lung cancer[1].
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SMU-H1 | SMU-H1 is a TLR2 agonist with a KD of 12.1 nM for mouse TLR2 and an EC50 of 5.14 nM in HEK-Blue hTLR2 cells. SMU-H1 binds TLR2 and activates MyD88-dependent signaling. SMU-H1 activates the NF-κB and MAPK signaling pathways. SMU-H1 induces proinflammatory cytokine production. SMU-H1 promotes M1 macrophage polarization and dendritic cell activation. SMU-H1 can be used for research on Lewis lung cancer. | |||||||||||||||||||||
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