2411174-53-1
2411174-53-1
Chemical Structure
VEGFR-2-IN-23
- CAS No.: 2411174-53-1
- Formula:C22H15N5O2
- Molecular Weight:381.39
IUPAC Name: 2-hydrazinyl-6-(naphthalen-2-yl)-4-(4-nitrophenyl)nicotinonitrile
InChIKey: HKSGWKJRWMNWAL-UHFFFAOYSA-N
SMILES: N#CC1=C(N=C(C=C1C2=CC=C(C=C2)[N+]([O-])=O)C3=CC4=CC=CC=C4C=C3)NN
Biological Activity: VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].
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VEGFR-2-IN-23 | VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase. | |||||||||||||||||||||
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