2411226-02-1
Chemical Structure
BET bromodomain inhibitor 1
- CAS No.: 2411226-02-1
- Formula:C22H19F2N3O4S
- Molecular Weight:459.47
IUPAC Name: 6-(2-(2,4-difluorophenoxy)-5-((ethylsulfonyl)methyl)pyridin-3-yl)-8-methylpyrrolo[1,2-a]pyrazin-1(2H)-one
InChIKey: UETQFSCWDMJWMM-UHFFFAOYSA-N
SMILES: O=C1C2=C(C)C=C(C3=CC(CS(=O)(CC)=O)=CN=C3OC4=CC=C(F)C=C4F)N2C=CN1
Biological Activity: BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. BET bromodomain inhibitor 1 binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). bromodomain inhibitor 1 has anti-cancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BET bromodomain inhibitor 1 | 99.67% | BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. BET bromodomain inhibitor 1 binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). bromodomain inhibitor 1 has anti-cancer activity. | ||||||||||||||||||||
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