2411497-72-6
Chemical Structure
IRAK4-IN-33
- CAS No.: 2411497-72-6
- Formula:C27H26N10OS
- Molecular Weight:538.63
InChIKey: OWLQPODHCJMRNB-POTSHQGWSA-N
SMILES: CC(N[C@H]1[C@@H]2CN(C3=NN=C(C4=C(N[C@@H](C#N)C)C=C(C5=CC=C6C=C(C#N)C=NN65)N=C4)S3)C[C@H]1CC2)=O
Biological Activity: IRAK4-IN-33 (Compound 22) is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 0.36 nM. IRAK4-IN-33 can block the pro-inflammatory signaling pathway mediated by IRAK4 and inhibit the release of TNFα and IFNα. IRAK4-IN-33 shows weak inhibition for hERG channel (IC50 > 30 μM). IRAK4-IN-33 can be used for the research of inflammation and immunology, such as rheumatoid arthritis[1].
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IRAK4-IN-33 | IRAK4-IN-33 (Compound 22) is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 0.36 nM. IRAK4-IN-33 can block the pro-inflammatory signaling pathway mediated by IRAK4 and inhibit the release of TNFα and IFNα. IRAK4-IN-33 shows weak inhibition for hERG channel (IC50 > 30 μM). IRAK4-IN-33 can be used for the research of inflammation and immunology, such as rheumatoid arthritis. | |||||||||||||||||||||
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