2411873-31-7
2411873-31-7
Chemical Structure
LDC8201
- CAS No.: 2411873-31-7
- Formula:C28H28ClN5O
- Molecular Weight:486.02
IUPAC Name: N-(5-(4-chloro-2-(4-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-methylphenyl)acrylamide
InChIKey: HYCCPTUSPYOPRE-UHFFFAOYSA-N
SMILES: O=C(C=C)NC=1C=C(C=CC1C)C2=C(NC3=NC=CC(Cl)=C32)C=4C=CC(=CC4)N5CCN(C)CC5
Biological Activity: LDC8201 is a selective, orally active, covalent inhibitor that targets EGFR and Her2 exon 20 insertion mutants. LDC8201 induces tumor shrinkage and regression. LDC8201 is applicable to research related to non-small cell lung cancer carrying EGFR or Her2 exon 20 insertion mutations[1][2].
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LDC8201 | LDC8201 is a selective, orally active, covalent inhibitor that targets EGFR and Her2 exon 20 insertion mutants. LDC8201 induces tumor shrinkage and regression. LDC8201 is applicable to research related to non-small cell lung cancer carrying EGFR or Her2 exon 20 insertion mutations. | |||||||||||||||||||||
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References
- [1]. Tumbrink H L. 3.3 MIZ1-∆ POZ shapes treatment response in small cell lung cancer[J]. Exploiting molecular vulnerabilities in genetically defined lung cancer models, 2023: 45.
- [2]. Lategahn J, et al. Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. Journal of medicinal chemistry. 2022 May 12;65(9):6643-6655. [Content Brief]
