2411955-43-4
2411955-43-4
Chemical Structure
HDAC6/HSP90-IN-1
- CAS No.: 2411955-43-4
- Formula:C28H37N3O6
- Molecular Weight:511.61
IUPAC Name: N1-(2-(2,4-dihydroxy-5-isopropylbenzoyl)isoindolin-5-yl)-N10-hydroxydecanediamide
InChIKey: HBNSYDADLFRPNT-UHFFFAOYSA-N
SMILES: CC(C1=C(C=C(C(C(N2CC3=CC=C(C=C3C2)NC(CCCCCCCCC(NO)=O)=O)=O)=C1)O)O)C
Biological Activity: HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].
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HDAC6/HSP90-IN-1 | HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice. | |||||||||||||||||||||
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