2411962-64-4
2411962-64-4
Chemical Structure
Microtubule inhibitor 4
- CAS No.: 2411962-64-4
- Formula:C25H23FN4O3
- Molecular Weight:446.47
IUPAC Name: (Z)-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-6-((Z)-3-(4-fluorophenoxy)benzylidene)piperazine-2,5-dione
InChIKey: CALJDDPCVHTIDS-FDYZEBBJSA-N
SMILES: CC(C)(C1=C(N=CN1)/C=C2NC(/C(NC\2=O)=C/C3=CC(OC4=CC=C(C=C4)F)=CC=C3)=O)C
Biological Activity: Microtubule inhibitor 4 (compound 2) is a potent microtubule inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC50s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization[1].
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Microtubule inhibitor 4 | Microtubule inhibitor 4 (compound 2) is a potent microtubule inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC50s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization. | |||||||||||||||||||||
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