2411969-28-1
2411969-28-1
Chemical Structure
Notum-IN-2
- CAS No.: 2411969-28-1
- Formula:C9H4ClF3N2O2
- Molecular Weight:264.59
InChIKey: SBBOPUCCCOEMDA-UHFFFAOYSA-N
SMILES: O=C1OC(C2=CC(C(F)(F)F)=C(Cl)C=C2)=NN1
Biological Activity: Notum-IN-2 is a partially brain-penetrant Notum carboxyl-esterase inhibitor with an IC50 of 18 nM. Notum-IN-2 can be used as a chemical tool for exploring Wnt signalling in cells[1][2].
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Notum-IN-2 | Notum-IN-2 is a partially brain-penetrant Notum carboxyl-esterase inhibitor with an IC50 of 18 nM. Notum-IN-2 can be used as a chemical tool for exploring Wnt signalling in cells. | |||||||||||||||||||||
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References
- [1]. Li ASM, et al. Discovery of Nanomolar DCAF1 Small Molecule Ligands. J Med Chem. 2023;66(7):5041-5060. [Content Brief]
- [2]. Mahy W, et al. 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. J Med Chem. 2020 Nov 12;63(21):12942-12956. [Content Brief]
