2412367-83-8
2412367-83-8
Chemical Structure
HA-9104
- CAS No.: 2412367-83-8
- Formula:C28H27N5O2
- Molecular Weight:465.55
InChIKey: CUVLCKLPYDVJQN-MDWZMJQESA-N
SMILES: O=C(NC1=CC=C(N2CCN(CC2)C(C3=CC=C(C)C=C3)=O)C=C1)/C=C/C4=CNC5=C4C=CC=N5
Biological Activity: HA-9104 is a potent and selective inhibitor of cullin-5 neddylation via virtually targeting the V30 pocket of UBE2F. HA-9104 binds to UBE2F, reduces its protein levels, and consequently inhibits cullin-5 neddylation. HA-9104 has potent growth suppression and radiosensitizing activities via targeting the UBE2F-CRL5 axis and causing DNA damage, leading to induction of apoptosis and G2/M arrest in lung and pancreatic cancer cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HA-9104 | 98.58% | HA-9104 is a potent and selective inhibitor of cullin-5 neddylation via virtually targeting the V30 pocket of UBE2F. HA-9104 binds to UBE2F, reduces its protein levels, and consequently inhibits cullin-5 neddylation. HA-9104 has potent growth suppression and radiosensitizing activities via targeting the UBE2F-CRL5 axis and causing DNA damage, leading to induction of apoptosis and G2/M arrest in lung and pancreatic cancer cells. | ||||||||||||||||||||
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