2412580-47-1
2412580-47-1
Chemical Structure
LP-284
- CAS No.: 2412580-47-1
- Formula:C16H20N2O4
- Molecular Weight:304.34
IUPAC Name: (S)-1-hydroxy-1-((6'-hydroxy-2',4',6'-trimethyl-7'-oxo-6',7'-dihydrospiro[cyclopropane-1,5'-inden]-3'-yl)methyl)urea
InChIKey: VWMPVAZEBAKLFR-OAHLLOKOSA-N
SMILES: CC(C1(CC1)[C@@](O)(C)C2=O)=C3C2=CC(C)=C3CN(C(N)=O)O
Biological Activity: LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL)[1][2].
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LP-284 | LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL). | |||||||||||||||||||||
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References
- [1]. Zhou J, et al. MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S396. [Content Brief]
- [2]. Zhou J, et al. The Positive Enantiomer of a Novel Chiral DNA Alkylating Agent Exhibits Nanomolar Potency in Hematologic Cancers. Blood, 2021, 138: 3991.
