2412715-30-9
2412715-30-9
Chemical Structure
ERβ agonist-1
- CAS No.: 2412715-30-9
- Formula:C25H36O2
- Molecular Weight:368.55
SMILES: CC(CCC[C@]12C(C[C@H](C1)O)=C3CCC4=C(C(O)=CC=C4[C@]3(CC2)C)C)C
Biological Activity: ERβ agonist-1 (Compound 8) is a dual-active selective ERβ agonist (EC50: 46.8 nM) and AR antagonist (IC50: 1555 nM). ERβ agonist-1 activates ERβ signaling by binding to ERβ and inhibits AR activity. ERβ agonist-1 retains selective ERβ agonist activity in mouse models and can be used to study prostate cancer[1].
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ERβ agonist-1 | ERβ agonist-1 (Compound 8) is a dual-active selective ERβ agonist (EC50: 46.8 nM) and AR antagonist (IC50: 1555 nM). ERβ agonist-1 activates ERβ signaling by binding to ERβ and inhibits AR activity. ERβ agonist-1 retains selective ERβ agonist activity in mouse models and can be used to study prostate cancer. | |||||||||||||||||||||
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