2413901-61-6
2413901-61-6
Chemical Structure
Topoisomerase II inhibitor 9
- CAS No.: 2413901-61-6
- Formula:C22H17N7O3S2
- Molecular Weight:491.55
IUPAC Name: 2-([1,2,4]triazolo[4,3-a]quinoxalin-4-ylthio)-N-(4-(N-(pyridin-2-yl)sulfamoyl)phenyl)acetamide
InChIKey: LHFXYOYUZZPXSR-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(S(=O)(NC2=NC=CC=C2)=O)C=C1)CSC3=NC4=C(N5C3=NN=C5)C=CC=C4
Biological Activity: Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1].
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Topoisomerase II inhibitor 9 | Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells. | |||||||||||||||||||||
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